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Q & A: Current Biology, Vol. 13, No. 13. (1 July 2003), pp. R501-R502.Alex ander Varshavsky is Smits Professor of Cell Biology at the California Institute of Technology. He moved to Caltech in 1992, after 15 years at the MIT's Department of Biology. He was born and educated in Russia, and was 30 at the time of his emigration to the U.S. in 1977. In Russia, and for a while at MIT, he studied the structure and replication of chromosomes. Over the last 24 years, the work of his laboratory focused on the ubiquitin system and closely related fields. He is a member of the U.S. National Academy of Sciences, and has received the Gairdner Award, the Lasker Award, the General Motors Sloan Prize, the Wolf Prize, the Horwitz Prize, and the Wilson Medal.

Source: Current Biology, Vol. 13, No. 13. (1 July 2003), pp. R501-R502.
Ten Simple Rules for Doing Your Best Research, According to Hamming: PLoS Computational Biology, Vol. 3, No. 10. (1 October 2007), e213.

Source: PLoS Computational Biology, Vol. 3, No. 10. (1 October 2007), e213.
Wiki's wild world: Nature, Vol. 438, No. 7070. (15 December 2005), pp. 890-890.

Source: Nature, Vol. 438, No. 7070. (15 December 2005), pp. 890-890.
Writing a research paper: Current Paediatrics, Vol. 14, No. 6. (November 2004), pp. 513-518.Summar yThe aim of this article is to help those embarking on research to communicate effectively through writing, and to improve their chances of getting a paper published. The quality of a paper's research content is judged by originality, importance and scientific validity. Advice should be sought on a project's potential for high-quality research content before taking up the research. When readers have difficulties in understanding a paper, the problem more often lies with presentation and structure than with its scientific content. Readers expect information to be presented in a certain way and when this does not happen they may misinterpret what the writer intended.

Source: Current Paediatrics, Vol. 14, No. 6. (November 2004), pp. 513-518.
Online methods share insider tricks: Nature, Vol. 441, No. 7094. (07 June 2006), pp. 678-678.

Source: Nature, Vol. 441, No. 7094. (07 June 2006), pp. 678-678.
The Craft of Research (Chicago Guides to Writing, Editing, and Publishing): (02 October 1995)Skillfull y done, research can be the solid cornerstone of your term paper (or dissertation, essay, or article); inadequately executed, it can cause your whole project to crumble and fall. Yet essential as research is to the ultimate success of your work, performing it is not an innate talent. The precepts, steps, and skills of solid research are readily acquired if you spend some time with The Craft of Research before you start on your outlines and thesis statements. Written by three distinguished professors in 1995, published by the University of Chicago, and winner of the 1995-96 Critics' Choice Award, The Craft of Research teaches how to plan, carry out, and report on research for any field and at any level. Aimed at assisting student researchers, from raw beginners to accomplished graduate and professional students, the book shows how to choose a topic, plan and organize research, and how to draft and revise a report of findings such that a convincing solution is offered to a significant problem. The Craft of Research is more than just another instruction manual getting you from topic to outline to notes to report. Recognizing that good research is rarely a simple, sequential procedure, but is instead a complex and intricate process, it discusses the subtle ways in which asking questions about your topic can influence how you draft your report, how a quality introduction can send you back to the library, and how the process of drafting can highlight flaws in your argument that need to be addressed. Clear and explicit, sophisticated and practical, The Craft of Research encourages high standards of scholarly achievement, and spells out the steps by which to get there. --Stephanie Gold This manual offers practical advice on the fundamentals of research to college and university students in all fields of study. The Craft of Research teaches much more than the mechanics of fact gathering: it explains how to approach a research project as an analytical process. The authors chart every stage of research, from finding a topic and generating research questions about it to marshalling evidence, constructing arguments, and writing everything up in a final report that is a model of authority. Their advice is designed for use by both beginners and seasoned practitioners, and for projects from class papers to dissertations. This book is organized into four parts. Part One is a spirited introduction to the distinctive nature, values, and protocols of research. Part Two demystifies the art of discovering a topic. It outlines a wide range of sources, among them personal interests and passions. Parts Three and Four cover the essentials of argument--how to make a claim and support it--and ways to outline, draft, revise, rewrite, and polish the final report. Part Three is a short course in the logic, structure, uses, and common pitfalls of argumentation. The writing chapters in Part Four show how to present verbal and visual information effectively and how to shape sentences and paragraphs that communicate with power and precision."A well-construct ed, articulate reminder of how important fundamental questions of style and approach, such as clarity and precision, are to all research."--Ti mes Literary Supplement

Source: (02 October 1995)
Experts plan to reclaim the web for pop science: Nature, Vol. 439, No. 7076. (01 February 2006), pp. 516-517.

Source: Nature, Vol. 439, No. 7076. (01 February 2006), pp. 516-517.
The path to ubiquitous and low-cost organic electronic appliances on plastic: Nature, Vol. 428, No. 6986. (29 April 2004), pp. 911-918.

Source: Nature, Vol. 428, No. 6986. (29 April 2004), pp. 911-918.
Evaluation of the current knowledge limitations in breast cancer research: a gap analysis: Breast Cancer Research, Vol. 10 (27 March 2008), R26.BACKGROUND : A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients. METHODS: Fifty-six Breast Cancer Campaign grant holders and prominent UK breast cancer researchers participated in a gap analysis of current breast cancer research. Before, during and following the meeting, groups in seven key research areas participated in cycles of presentation, literature review and discussion. Summary papers were prepared by each group and collated into this position paper highlighting the research gaps, with recommendation s for action. RESULTS: Gaps were identified in all seven themes. General barriers to progress were lack of financial and practical resources, and poor collaboration between disciplines. Critical gaps in each theme included: (1) genetics (knowledge of genetic changes, their effects and interactions); (2) initiation of breast cancer (how developmental signalling pathways cause ductal elongation and branching at the cellular level and influence stem cell dynamics, and how their disruption initiates tumour formation); (3) progression of breast cancer (deciphering the intracellular and extracellular regulators of early progression, tumour growth, angiogenesis and metastasis); (4) therapies and targets (understanding who develops advanced disease); (5) disease markers (incorporating intelligent trial design into all studies to ensure new treatments are tested in patient groups stratified using biomarkers); (6) prevention (strategies to prevent oestrogen-rece ptor negative tumours and the long-term effects of chemopreventio n for oestrogen-rece ptor positive tumours); (7) psychosocial aspects of cancer (the use of appropriate psychosocial interventions, and the personal impact of all stages of the disease among patients from a range of ethnic and demographic backgrounds). CONCLUSION: Through recommendation s to address these gaps with future research, the long-term benefits to patients will include: better estimation of risk in families with breast cancer and strategies to reduce risk; better prediction of drug response and patient prognosis; improved tailoring of treatments to patient subgroups and development of new therapeutic approaches; earlier initiation of treatment; more effective use of resources for screening populations; and an enhanced experience for people with or at risk of breast cancer and their families. The challenge to funding bodies and researchers in all disciplines is to focus on these gaps and to drive advances in knowledge into improvements in patient care.

Source: Breast Cancer Research, Vol. 10 (27 March 2008), R26.
Urinary Estrone Conjugate and Pregnanediol 3-Glucuronide Enzyme Immunoassays for Population Research: Clin Chem, Vol. 49, No. 7. (1 July 2003), pp. 1139-1148.Back ground: Monitoring of reproductive steroid hormones at the population level requires frequent measurements, hormones or metabolites that remain stable under less than ideal collection and storage conditions, a long-term supply of antibodies, and assays useful for a range of populations. We developed enzyme immunoassays for urinary pregnanediol 3-glucuronide (PDG) and estrone conjugates (E1Cs) that meet these criteria. Methods: Enzyme immunoassays based on monoclonal antibodies were evaluated for specificity, detection limit, parallelism, recovery, and imprecision. Paired urine and serum specimens were analyzed throughout menstrual cycles of 30 US women. Assay application in different populations was examined with 23 US and 42 Bangladeshi specimens. Metabolite stability in urine was evaluated for 0-8 days at room temperature and for 0-10 freeze-thaw cycles. Results: Recoveries were 108% for the PDG assay and 105% for the E1C assay. Serially diluted specimens exhibited parallelism with calibration curves in both assays. Inter- and intraassay CVs were

Source: Clin Chem, Vol. 49, No. 7. (1 July 2003), pp. 1139-1148.

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